Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment

INTRODUCTION: KRAS and EGFR ectodomain-acquired mutations in patients with metastatic colorectal cancer (mCRC) have been correlated with acquired resistance to anti-EGFR monoclonal antibodies (mAbs). We investigated the frequency, co-occurrence, and distribution of acquired KRAS and EGFR mutations i...

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Detalhes bibliográficos
Publicado no:Ann Oncol
Main Authors: Morelli, M. P., Overman, M. J., Dasari, A., Kazmi, S. M. A., Mazard, T., Vilar, E., Morris, V. K., Lee, M. S., Herron, D., Eng, C., Morris, J., Kee, B. K., Janku, F., Deaton, F. L., Garrett, C., Maru, D., Diehl, F., Angenendt, P., Kopetz, S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374387/
https://ncbi.nlm.nih.gov/pubmed/25628445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdv005
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