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Lagging strand replication shapes the mutational landscape of the genome
The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here, we report that the 5′-ends of Okazaki fragments have significantly elevated levels of nucleotide substitu...
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| Publié dans: | Nature |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4374164/ https://ncbi.nlm.nih.gov/pubmed/25624100 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14183 |
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