TopBP1 Interacts with BLM to Maintain Genome Stability but Is Dispensable for Preventing BLM Degradation

The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013). Here, we...

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Publicado en:Mol Cell
Main Authors: Blackford, Andrew N., Nieminuszczy, Jadwiga, Schwab, Rebekka A., Galanty, Yaron, Jackson, Stephen P., Niedzwiedz, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2015
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Matters Arising
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374139/
https://ncbi.nlm.nih.gov/pubmed/25794620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.012
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