Thioredoxin-2 Inhibits Mitochondrial ROS Generation and ASK1 Activity to Maintain Cardiac Function

BACKGROUND: Thioredoxin 2 (Trx2) is a key mitochondrial protein which regulates cellular redox and survival by suppressing mitochondrial ROS generation and by inhibiting apoptosis stress kinase-1 (ASK1)-dependent apoptotic signaling. To date, the role of the mitochondrial Trx2 system in heart failur...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Huang, Qunhua, Zhou, Huanjiao Jenny, Zhang, Haifeng, Huang, Yan, Hinojosa-Kirschenbaum, Ford, Fan, Peidong, Yao, Lina, Belardinelli, Luiz, Tellides, George, Giordano, Frank J., Budas, Grant R., Min, Wang
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374031/
https://ncbi.nlm.nih.gov/pubmed/25628390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.012725
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