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Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport

Leelamine is a promising compound for the treatment of cancer; however, the molecular mechanisms leading to leelamine-mediated cell death have not been identified. This report shows that leelamine is a weakly basic amine with lysosomotropic properties, leading to its accumulation inside acidic organ...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Kuzu, Omer F., Gowda, Raghavendra, Sharma, Arati, Robertson, Gavin P.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373557/
https://ncbi.nlm.nih.gov/pubmed/24688051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0868
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