Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8(+) CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70

Exosomes (EXO) derived from tumour cells have been used to stimulate antitumour immune responses, but only resulting in prophylatic immunity. Tumour-derived heat shock protein 70 (HSP70) molecules are molecular chaperones with a broad repertoire of tumour antigen peptides capable of stimulating dend...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Xie, Yufeng, Bai, Ou, Zhang, Haifeng, Yuan, Jinying, Zong, Sam, Chibbar, Rajni, Slattery, Karen, Qureshi, Mabood, Wei, Yangdou, Deng, Yulin, Xiang, Jim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373481/
https://ncbi.nlm.nih.gov/pubmed/19627400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00851.x
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