Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy

The protein LC3 is indispensible for the cellular recycling process of autophagy and plays critical roles during cargo recruitment, autophagosome biogenesis, and completion. Here, we report that LC3 is phosphorylated at threonine 50 (Thr(50)) by the mammalian sterile-20 kinases STK3 and STK4. Loss o...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Cell
Главные авторы: Wilkinson, Deepti S., Jariwala, Jinel S, Anderson, Ericka, Mitra, Koyel, Meisenhelder, Jill, Chang, Jessica T., Ideker, Trey, Hunter, Tony, Nizet, Victor, Dillin, Andrew, Hansen, Malene
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373083/
https://ncbi.nlm.nih.gov/pubmed/25544559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.019
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы