Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy

The protein LC3 is indispensible for the cellular recycling process of autophagy and plays critical roles during cargo recruitment, autophagosome biogenesis, and completion. Here, we report that LC3 is phosphorylated at threonine 50 (Thr(50)) by the mammalian sterile-20 kinases STK3 and STK4. Loss o...

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Pubblicato in:Mol Cell
Autori principali: Wilkinson, Deepti S., Jariwala, Jinel S, Anderson, Ericka, Mitra, Koyel, Meisenhelder, Jill, Chang, Jessica T., Ideker, Trey, Hunter, Tony, Nizet, Victor, Dillin, Andrew, Hansen, Malene
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373083/
https://ncbi.nlm.nih.gov/pubmed/25544559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.019
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