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Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders
Phosphoinositides are membrane components that play critical regulatory roles in mammalian cells. The enzyme PTEN, which catalyzes the dephosphorylation of the phosphoinositide PIP(3), is damaged in most sporadic tumors. Mutations in the PTEN gene have also been linked to autism spectrum disorders a...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372197/ https://ncbi.nlm.nih.gov/pubmed/25647146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00028 |
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