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Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders

Phosphoinositides are membrane components that play critical regulatory roles in mammalian cells. The enzyme PTEN, which catalyzes the dephosphorylation of the phosphoinositide PIP(3), is damaged in most sporadic tumors. Mutations in the PTEN gene have also been linked to autism spectrum disorders a...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Johnston, Sean B., Raines, Ronald T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372197/
https://ncbi.nlm.nih.gov/pubmed/25647146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00028
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