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Endosome traffic machinery meets the p53–p21 axis
SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK...
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| Publicado en: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372196/ https://ncbi.nlm.nih.gov/pubmed/25815376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723556.2014.975075 |
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