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Tandem Mass Spectrometry Assays of Palmitoyl Protein Thioesterase 1 and Tripeptidyl Peptidase Activity in Dried Blood Spots for the Detection of Neuronal Ceroid Lipofuscinoses in Newborns

[Image: see text] We report new substrates for quantitative enzyme activity measurements of human palmitoyl protein thioesterase (PPT1) and tripeptidyl peptidase (TPP1) in dried blood spots from newborns using tandem mass spectrometry. Deficiencies in these enzyme activities due to inborn errors of...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Barcenas, Mariana, Xue, Chang, Marushchak-Vlaskin, Tatyana, Scott, C. Ronald, Gelb, Michael H., Tureček, František
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372105/
https://ncbi.nlm.nih.gov/pubmed/25019629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac501994b
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