Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Zfp335(bloto/bloto) mice exhibit a naïv...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Han, Brenda Y, Wu, Shuang, Foo, Chuan-Sheng, Horton, Robert M, Jenne, Craig N, Watson, Susan R, Whittle, Belinda, Goodnow, Chris C, Cyster, Jason G
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
Schlagworte:
Genes and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371841/
https://ncbi.nlm.nih.gov/pubmed/25343476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03549
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