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Interferon gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence
Vertebrate hematopoietic stem cells (HSCs) emerge in the aorta-gonad-mesonephros (AGM) region from “hemogenic” endothelium. Here we show that the pro-inflammatory cytokine Ifn-γ and its receptor Crfb17 positively regulate HSC development in zebrafish. This regulation does not appear to modulate the...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371141/ https://ncbi.nlm.nih.gov/pubmed/25490269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.11.007 |
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