Determining the Polymer Threshold Amount for Achieving Robust Drug Release from HPMC and HPC Matrix Tablets Containing a High-Dose BCS Class I Model Drug: In Vitro and In Vivo Studies

It is challenging to achieve mechanically robust drug-release profiles from hydrophilic matrices containing a high dose of a drug with good solubility. However, a mechanically robust drug release over prolonged period of time can be achieved, especially if the viscosity and amount of the polymer is...

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Vydáno v:AAPS PharmSciTech
Hlavní autoři: Klančar, Uroš, Baumgartner, Saša, Legen, Igor, Smrdel, Polona, Kampuš, Nataša Jeraj, Krajcar, Dejan, Markun, Boštjan, Kočevar, Klemen
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370964/
https://ncbi.nlm.nih.gov/pubmed/25331194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-014-0234-4
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