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A Novel Beads-Based Dissolution Method for the In Vitro Evaluation of Extended Release HPMC Matrix Tablets and the Correlation with the In Vivo Data

The aim of this work was to establish alternative in vitro dissolution method with good discrimination and in vivo predictability for the evaluation of HPMC extended release matrix tablets. For this purpose, two different HPMC matrix tablet formulations were first evaluated by a range of conventiona...

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Autori principali: Klančar, Uroš, Markun, Boštjan, Baumgartner, Saša, Legen, Igor
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535107/
https://ncbi.nlm.nih.gov/pubmed/23188526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9422-x
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