DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status

Cholangiocarcinoma (CCA) is a cancer arising from the neoplastic transformation of cholangiocytes. During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Zebularine (1-(β-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one...

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Veröffentlicht in:PLoS One
Hauptverfasser: Nakamura, Kazuaki, Nakabayashi, Kazuhiko, Htet Aung, Kyaw, Aizawa, Kazuko, Hori, Naoko, Yamauchi, Junji, Hata, Kenichiro, Tanoue, Akito
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370694/
https://ncbi.nlm.nih.gov/pubmed/25799509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120545
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