Involvement of Cytochrome P450 1A1 and Glutathione S-Transferase P1 Polymorphisms and Promoter Hypermethylation in the Progression of Anti-Tuberculosis Drug-Induced Liver Injury: A Case–Control Study

BACKGROUND: Anti-tuberculosis (anti-TB) drug-induced liver injury (ADLI) is one of the most common adverse effects associated with TB treatment. Cytochrome P450 (CYP) 1A1 and glutathione S-transferase (GST) P1 are important phase I/II metabolizing enzymes involved in drug metabolism and detoxificati...

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Publicado no:PLoS One
Main Authors: He, Lei, Gao, Li, Shi, Zhe, Li, Yuhong, Zhu, Lingyan, Li, Shiming, Zhang, Peng, Zheng, Guoying, Ren, Qi, Li, Yun, Hu, Bo, Feng, Fumin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370371/
https://ncbi.nlm.nih.gov/pubmed/25798582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119481
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