Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria

Interleukin-21 signaling is important for germinal center B-cell responses, isotype switching and generation of memory B cells. However, a role for IL-21 in antibody-mediated protection against pathogens has not been demonstrated. Here we show that IL-21 is produced by T follicular helper cells and...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Pérez-Mazliah, Damián, Ng, Dorothy Hui Lin, Freitas do Rosário, Ana Paula, McLaughlin, Sarah, Mastelic-Gavillet, Béatris, Sodenkamp, Jan, Kushinga, Garikai, Langhorne, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370355/
https://ncbi.nlm.nih.gov/pubmed/25763578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004715
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