Follicular Helper T Cells are Essential for the Elimination of Plasmodium Infection

CD4+ follicular helper T (Tfh) cells have been shown to be critical for the activation of germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection activates both GC as well as non-GC B cell responses. Here, we sought to explore whether Tfh cells and GC B cells are req...

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Detalhes bibliográficos
Main Authors: Damián Pérez-Mazliah, Minh Phuong Nguyen, Caroline Hosking, Sarah McLaughlin, Matthew D. Lewis, Irene Tumwine, Prisca Levy, Jean Langhorne
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-10-01
Colecção:EBioMedicine
Assuntos:
Follicular helper T (Tfh) cells
Plasmodium
Vector transmission
Signaling Lymphocyte Activation Molecule (SLAM)-Associated Protein (SAP)
GC B cells
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S235239641730347X
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