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Chronic blockade of endothelin A and B receptors using macitentan in experimental renovascular disease

BACKGROUND: Emerging research has identified the endothelin (ET)-1 pathway as a potential target for novel renoprotective therapies. We recently showed that selective ET-A receptor antagonism in chronic renovascular disease (RVD) improves renal function and reduces renal injury. Although ET-A and -B...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Tullos, Nathan A., Stewart, Nicholas J., Davidovich, Ryan, Chade, Alejandro R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370292/
https://ncbi.nlm.nih.gov/pubmed/25438341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfu361
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