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Endothelin-A receptor blockade slows the progression of renal injury in experimental renovascular disease

Endothelin (ET)-1, a potent renal vasoconstrictor with mitogenic properties, is upregulated by ischemia and has been shown to induce renal injury via the ET-A receptor. The potential role of ET-A blockade in chronic renovascular disease (RVD) has not, to our knowledge, been previously reported. We h...

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Détails bibliographiques
Auteurs principaux: Kelsen, Silvia, Hall, John E., Chade, Alejandro R.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129888/
https://ncbi.nlm.nih.gov/pubmed/21478482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00089.2011
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