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The phenotypic expression of mitochondrial tRNA-mutations can be modulated by either mitochondrial leucyl-tRNA synthetase or the C-terminal domain thereof

Mutations in mitochondrial (mt) DNA determine important human diseases. The majority of the known pathogenic mutations are located in transfer RNA (tRNA) genes and are responsible for a wide range of currently untreatable disorders. Experimental evidence both in yeast and in human cells has shown th...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Front Genet
मुख्य लेखकों: Giordano, Carla, Morea, Veronica, Perli, Elena, d’Amati, Giulia
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370040/
https://ncbi.nlm.nih.gov/pubmed/25852750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00113
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