ALK and ROS1 as a joint target for the treatment of lung cancer: a review

Rearrangements of the anaplastic lymphoma kinase (ALK) have been described in multiple malignancies, including non-small cell lung cancer (NSCLC). ALK fusions have gain of function properties while activating mutations in wild-type ALK can also occur within the tyrosine kinase domain. ALK rearrangem...

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Detalhes bibliográficos
Publicado no:Transl Lung Cancer Res
Main Authors: Puig de la Bellacasa, Raimon, Karachaliou, Niki, Estrada-Tejedor, Roger, Teixidó, Jordi, Costa, Carlota, Borrell, José I.
Formato: Artigo
Idioma:Inglês
Publicado em: Pioneer Bioscience Publishing Company 2013
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369855/
https://ncbi.nlm.nih.gov/pubmed/25806218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2218-6751.2013.03.1
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