Pyridoxal phosphate as an antisickling agent in vitro.

Although pyridoxal phosphate is known to inhibit gelation of purified hemoglobin S, antisickling activity has never been demonstrated for intact erythrocytes. We incubated washed erythrocytes at 37 degrees C either in buffer alone, or with added pyridoxal phosphate or pyridoxal, washed these cells,...

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Pubblicato in:	J Clin Invest
Autori principali:	Kark, J A, Tarassoff, P G, Bongiovanni, R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1983
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC436982/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6853710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110871
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