4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer

Hyaluronan (HA) is a prominent component of the extracellular matrix at many sites of chronic inflammation, including type 1 diabetes (T1D), multiple sclerosis, and numerous malignancies. Recent publications have demonstrated that when HA synthesis is inhibited using 4-methylumbelliferone (4-MU), be...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Nagy, Nadine, Kuipers, Hedwich F., Frymoyer, Adam R., Ishak, Heather D., Bollyky, Jennifer B., Wight, Thomas N., Bollyky, Paul L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369655/
https://ncbi.nlm.nih.gov/pubmed/25852691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00123
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