Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer

PURPOSE: Obesity is associated with increased bioavailability of estrogen, hyperinsulemia and chronic inflammation, all of which may promote tumor growth. Given DNA repair and oxidative stress pathways may work together with these mechanisms to influence carcinogenesis, we hypothesized that genetic...

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Udgivet i:Ann Epidemiol
Main Authors: McCullough, Lauren E., Eng, Sybil M., Bradshaw, Patrick T., Cleveland, Rebecca J., Steck, Susan E., Terry, Mary Beth, Shen, Jing, Crew, Katherine D., Rossner, Pavel, Ahn, Jiyoung, Ambrosone, Christine B., Teitelbaum, Susan L., Neugut, Alfred I., Santella, Regina M., Gammon, Marilie D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369423/
https://ncbi.nlm.nih.gov/pubmed/25703993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.annepidem.2015.01.009
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