Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible and inhibits HIV-1 infectivity

The C-C chemokine receptor type 5 (CCR5) is a receptor expressed by T-cells and macrophages that serves as a co-receptor for macrophage-tropic HIV-1. Loss of CCR5 is associated with resistance to HIV-1. Here we combine the live cell-based SELEX with high throughput sequencing technology to generate...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Chem Biol
Asıl Yazarlar: Zhou, Jiehua, Satheesan, Sangeetha, Li, Haitang, Weinberg, Marc S., Morris, Kevin V., Burnett, John, Rossi, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369413/
https://ncbi.nlm.nih.gov/pubmed/25754473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.01.005
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