Beneficial effects of diminished production of hydrogen sulfide or carbon monoxide on hypertension and renal injury induced by NO withdrawal

BACKGROUND AND PURPOSE: Whether NO, carbon monoxide (CO) and hydrogen sulfide (H(2)S) compensate for each other when one or more is depleted is unclear. Inhibiting NOS causes hypertension and kidney injury. Both global depletion of H(2)S by cystathionine γ-lyase (CSE) gene deletion and low levels of...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Wesseling, Sebastiaan, Fledderus, Joost O, Verhaar, Marianne C, Joles, Jaap A
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Themed Section: Pharmacology of the Gasotransmitters
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369267/
https://ncbi.nlm.nih.gov/pubmed/24597655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12674
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