Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.

The dipyridodiazepinone Nevirapine is a potent and highly specific inhibitor of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). It is a member of an important class of nonnucleoside drugs that appear to share part or all of the same binding site on the enzyme but are...

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Bibliographic Details
Main Authors: Smerdon, S J, Jäger, J, Wang, J, Kohlstaedt, L A, Chirino, A J, Friedman, J M, Rice, P A, Steitz, T A
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC43692/
https://ncbi.nlm.nih.gov/pubmed/7513427
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