Yeast-based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites

Equilibrative transporters are potential drug targets, however most functional assays involve radioactive substrate uptake that is unsuitable for high-throughput screens (HTS). We developed a robust yeast-based growth assay that is potentially applicable to many equilibrative transporters. As proof...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Frame, I. J., Deniskin, Roman, Rinderspacher, Alison, Katz, Francine, Deng, Shi-Xian, Moir, Robyn D., Adjalley, Sophie H., Coburn-Flynn, Olivia, Fidock, David A., Willis, Ian M., Landry, Donald W., Akabas, Myles H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369170/
https://ncbi.nlm.nih.gov/pubmed/25602169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500981y
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