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Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man.

To assess the pharmacologic effects of aspirin on endogenous prostacyclin and thromboxane biosynthesis, 2,3-dinor-6-keto PGF1 alpha (PGI-M) and 2,3-dinor-thromboxane B2 (Tx-M) were measured in urine by mass spectrometry during continuing administration of aspirin. To define the relationship of aspir...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: FitzGerald, G A, Oates, J A, Hawiger, J, Maas, R L, Roberts, L J, Lawson, J A, Brash, A R
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1983
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC436917/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6338043/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110814
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