The tyrosine kinase adaptor protein FRS2 is oncogenic and amplified in high-grade serous ovarian cancer

High-grade serous ovarian cancers (HGSOC) are characterized by widespread recurrent regions of copy number gain and loss. Here we interrogated 50 genes that are recurrently amplified in HGSOC and essential for cancer proliferation and survival in ovarian cancer cell lines. FRS2 is one of the 50 gene...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer Res
Autori principali: Luo, Leo Y., Kim, Eejung, Cheung, Hiu Wing, Weir, Barbara A., Dunn, Gavin P., Shen, Rhine R., Hahn, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369154/
https://ncbi.nlm.nih.gov/pubmed/25368431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0407
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