Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation

BACKGROUND: Whole and partial chromosome losses or gains and structural chromosome changes are hallmarks of human tumors. Guanine-rich DNA, which has a potential to form a G-quadruplex (G(4)) structure, is particularly vulnerable to changes. In Caenorhabditis elegans, faithful transmission of G-rich...

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Détails bibliographiques
Publié dans:BMC Genomics
Auteurs principaux: Tarailo-Graovac, Maja, Wong, Tammy, Qin, Zhaozhao, Flibotte, Stephane, Taylor, Jon, Moerman, Donald G, Rose, Ann M, Chen, Nansheng
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369104/
https://ncbi.nlm.nih.gov/pubmed/25880765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1402-y
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