Determining Pharmacological Selectivity of the Kappa Opioid Receptor Antagonist LY2456302 Using Pupillometry as a Translational Biomarker in Rat and Human

BACKGROUND: Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression. The kappa opioid receptor antagonist, LY2456302, exhibits ~30-fold higher affinity for kappa opioid receptors over mu opioid receptors, which is the next closest identified ph...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Principais autores: Rorick-Kehn, Linda M., Witcher, Jennifer W., Lowe, Stephen L., Gonzales, Celedon R., Weller, Mary Ann, Bell, Robert L., Hart, John C., Need, Anne B., McKinzie, Jamie H., Statnick, Michael A., Suico, Jeffrey G., McKinzie, David L., Tauscher-Wisniewski, Sitra, Mitch, Charles H., Stoltz, Randall R., Wong, Conrad J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368892/
https://ncbi.nlm.nih.gov/pubmed/25637376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyu036
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