TLR7 Influences Germinal Center Selection in Murine SLE

TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain trans...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Boneparth, Alexis, Huang, Weiqing, Bethunaickan, Ramalingam, Woods, Megan, Sahu, Ranjit, Arora, Shitij, Akerman, Meredith, Lesser, Martin, Davidson, Anne
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368537/
https://ncbi.nlm.nih.gov/pubmed/25794167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119925
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