Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function are Neuroprotective with Minimal Side Effects

Stroke remains a significant problem despite decades of work on neuroprotective strategies. NMDA receptor (NMDAR) antagonists are neuroprotective in preclinical models, but have been clinically unsuccessful, in part due to side effects. Here we describe a prototypical GluN2B-selective antagonist wit...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Yuan, Hongjie, Myers, Scott J, Wells, Gordon, Nicholson, Katherine L, Swanger, Sharon A, Lyuboslavsky, Polina, Tahirovic, Yesim A, Menaldino, David S, Ganesh, Thota, Wilson, Lawrence J., Liotta, Dennis C, Snyder, James P, Traynelis, Stephen F
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368485/
https://ncbi.nlm.nih.gov/pubmed/25728572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.02.008
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