Impairment of Preimplantation Porcine Embryo Development by Histone Demethylase KDM5B Knockdown Through Disturbance of Bivalent H3K4me3-H3K27me3 Modifications

KDM5B (JARID1B/PLU1) is a H3K4me2/3 histone demethylase that is implicated in cancer development and proliferation and is also indispensable for embryonic stem cell self-renewal, cell fate, and murine embryonic development. However, little is known about the role of KDM5B during preimplantation embr...

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Dettagli Bibliografici
Pubblicato in:Biol Reprod
Autori principali: Huang, Jiaojiao, Zhang, Hongyong, Wang, Xianlong, Dobbs, Kyle B., Yao, Jing, Qin, Guosong, Whitworth, Kristin, Walters, Eric M., Prather, Randall S., Zhao, Jianguo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for the Study of Reproduction, Inc. 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367965/
https://ncbi.nlm.nih.gov/pubmed/25609834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.114.122762
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