Metformin directly targets the H3K27me3 demethylase KDM6A/UTX

Metformin, the first drug chosen to be tested in a clinical trial aimed to target the biology of aging per se, has been clinically exploited for decades in the absence of a complete understanding of its therapeutic targets or chemical determinants. We here outline a systematic chemoinformatics appro...

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Dettagli Bibliografici
Pubblicato in:Aging Cell
Autori principali: Cuyàs, Elisabet, Verdura, Sara, Llorach‐Pares, Laura, Fernández‐Arroyo, Salvador, Luciano‐Mateo, Fedra, Cabré, Noemí, Stursa, Jan, Werner, Lukas, Martin‐Castillo, Begoña, Viollet, Benoit, Neuzil, Jiri, Joven, Jorge, Nonell‐Canals, Alfons, Sanchez‐Martinez, Melchor, Menendez, Javier A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052472/
https://ncbi.nlm.nih.gov/pubmed/29740925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12772
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