Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs

BACKGROUND: Hypomethylation of long interspersed element (LINE)-1 has been observed in tumorigenesis when using degenerate assays, which provide an average across all repeats. However, it is unknown whether individual LINE-1 loci or different CpGs within one specific LINE-1 promoter are equally affe...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Nüsgen, Nicole, Goering, Wolfgang, Dauksa, Albertas, Biswas, Arijit, Jamil, Muhammad Ahmer, Dimitriou, Ioanna, Sharma, Amit, Singer, Heike, Fimmers, Rolf, Fröhlich, Holger, Oldenburg, Johannes, Gulbinas, Antanas, Schulz, Wolfgang A, El-Maarri, Osman
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367886/
https://ncbi.nlm.nih.gov/pubmed/25798207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0051-y
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