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BRAF mutant non-small cell lung cancer and treatment with BRAF inhibitors

Inhibitors targeting active protein kinases, such as EGFR or ALK, have demonstrated significant efficacy in the treatment of lung cancer. Activating mutations in the MAPK pathway, which includes the enzymes RAS, RAF, MEK, and ERK, result in constitutive signalling, leading to oncogenic cell prolifer...

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Bibliografske podrobnosti
izdano v:Transl Lung Cancer Res
Main Authors: Sánchez-Torres, José Miguel, Viteri, Santiago, Molina, Miguel Angel, Rosell, Rafael
Format: Artigo
Jezik:Inglês
Izdano: Pioneer Bioscience Publishing Company 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367599/
https://ncbi.nlm.nih.gov/pubmed/25806238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2218-6751.2013.04.01
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