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The Additive Damage Model: a Mathematical Model for Cellular Responses to Drug Combinations

Mathematical models to describe dose-dependent cellular responses to drug combinations are an essential component of computational simulations for predicting therapeutic responses. Here, a new model, the additive damage model, is introduced and tested in cases where varying concentrations of two dru...

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Detalhes bibliográficos
Publicado no:J Theor Biol
Main Authors: Jones, Leslie Braziel, Secomb, Timothy W., Dewhirst, Mark W., El-Kareh, Ardith W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367491/
https://ncbi.nlm.nih.gov/pubmed/24799130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2014.04.032
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