Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

Aims: Increased fructose consumption predisposes the liver to nonalcoholic fatty liver disease (NAFLD), but the mechanisms are elusive. Thioredoxin-interacting protein (TXNIP) links oxidative stress to NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation and this signa...

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Pubblicato in:Antioxid Redox Signal
Autori principali: Zhang, Xian, Zhang, Jian-Hua, Chen, Xu-Yang, Hu, Qing-Hua, Wang, Ming-Xing, Jin, Rui, Zhang, Qing-Yu, Wang, Wei, Wang, Rong, Kang, Lin-Lin, Li, Jin-Sheng, Li, Meng, Pan, Ying, Huang, Jun-Jian, Kong, Ling-Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2015
Soggetti:
Original Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367240/
https://ncbi.nlm.nih.gov/pubmed/25602171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.5868
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