The σ1 Receptor Engages the Redox-Regulated HINT1 Protein to Bring Opioid Analgesia Under NMDA Receptor Negative Control

Aims: The in vivo pharmacology of the sigma 1 receptor (σ1R) is certainly complex; however, σ1R antagonists are of therapeutic interest, because they enhance mu-opioid receptor (MOR)-mediated antinociception and reduce neuropathic pain. Thus, we investigated whether the σ1R is involved in the negati...

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Bibliographic Details
Published in:Antioxid Redox Signal
Main Authors: Rodríguez-Muñoz, María, Sánchez-Blázquez, Pilar, Herrero-Labrador, Raquel, Martínez-Murillo, Ricardo, Merlos, Manuel, Vela, José Miguel, Garzón, Javier
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2015
Subjects:
Original Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367239/
https://ncbi.nlm.nih.gov/pubmed/25557043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.5993
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