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Humoral and Cell-Mediated Immune Response, and Growth Factor Synthesis After Direct Intraarticular Injection of rAAV2-IGF-I and rAAV5-IGF-I in the Equine Middle Carpal Joint

Intraarticular (IA) administration of viral vectors expressing a therapeutic transgene is an attractive treatment modality for osteoarthritis (OA) as the joint can be treated as a contained unit. Humoral and cell-mediated immune responses in vivo can limit vector effectiveness. Transduction of artic...

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Bibliografske podrobnosti
izdano v:Hum Gene Ther
Main Authors: Ortved, Kyla, Wagner, Bettina, Calcedo, Roberto, Wilson, James, Schaefer, Deanna, Nixon, Alan
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367237/
https://ncbi.nlm.nih.gov/pubmed/25705927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2014.050
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