7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate.

Human subjects and rhesus monkeys receiving the antitumor agent methotrexate at the high dose levels recently introduced into clinical use (greater than 50 mg/kg) excrete significant amounts of the metabolite 7-hydroxymethotrexate. The metabolite is not detected in these species after methotrexate t...

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Hlavní autoři: Jacobs, S A, Stoller, R G, Chabner, B A, Johns, D G
Médium: Artigo
Jazyk:Inglês
Vydáno: 1976
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC436681/
https://ncbi.nlm.nih.gov/pubmed/1062383
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