Rapid Throughput Analysis Demonstrates that Chemicals with Distinct Seizurogenic Mechanisms Differentially Alter Ca(2+) Dynamics in Networks Formed by Hippocampal Neurons in Culture

Primary cultured hippocampal neurons (HN) form functional networks displaying synchronous Ca(2+) oscillations (SCOs) whose patterns influence plasticity. Whether chemicals with distinct seizurogenic mechanisms differentially alter SCO patterns was investigated using mouse HN loaded with the Ca(2+) i...

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Publicat a:Mol Pharmacol
Autors principals: Cao, Zhengyu, Zou, Xiaohan, Cui, Yanjun, Hulsizer, Susan, Lein, Pamela J., Wulff, Heike, Pessah, Isaac N.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366799/
https://ncbi.nlm.nih.gov/pubmed/25583085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.096701
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