Paradoxical Response to Mechanical Unloading in Bone Loss, Microarchitecture, and Bone Turnover Markers

Background: Sclerostin, encoded by the SOST gene, has been implicated in the response to mechanical loading in bone. Some studies demonstrated that unloading leads to up-regulated SOST expression, which may induce bone loss. Purpose: Most reported studies regarding the changes caused by mechanical u...

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Bibliographic Details
Published in:Int J Med Sci
Main Authors: Sun, Xiaodi, Yang, Kaiyun, Wang, Chune, Cao, Sensen, Merritt, Mackenzie, Hu, Yingwei, Xu, Xin
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366632/
https://ncbi.nlm.nih.gov/pubmed/25798053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.11078
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