Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated

The involvement of the ubiquitin-proteasome system (UPS) in the course of various age-associated neurodegenerative diseases is well established. The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson’s disease (PD) variant and was found to interact with ATXN2, a prot...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Halbach, Melanie Vanessa, Stehning, Tanja, Damrath, Ewa, Jendrach, Marina, Şen, Nesli Ece, Başak, A. Nazlı, Auburger, Georg
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366354/
https://ncbi.nlm.nih.gov/pubmed/25790475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121089
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items