Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria

In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond. These proteins include numerous bacterial virulence factors. Thus, bacterial enzymes that promote disulfide bond formation represent targets for compounds inhibiting bacterial virulence. Here, we...

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Gepubliceerd in:Nat Chem Biol
Hoofdauteurs: Landeta, Cristina, Blazyk, Jessica L., Hatahet, Feras, Meehan, Brian M., Eser, Markus, Myrick, Alissa, Bronstain, Ludmila, Minami, Shoko, Arnold, Holly, Ke, Na, Rubin, Eric J., Furie, Barbara C., Furie, Bruce, Beckwith, Jon, Dutton, Rachel, Boyd, Dana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366281/
https://ncbi.nlm.nih.gov/pubmed/25686372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1752
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