Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria

In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond. These proteins include numerous bacterial virulence factors. Thus, bacterial enzymes that promote disulfide bond formation represent targets for compounds inhibiting bacterial virulence. Here, we...

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Udgivet i:Nat Chem Biol
Main Authors: Landeta, Cristina, Blazyk, Jessica L., Hatahet, Feras, Meehan, Brian M., Eser, Markus, Myrick, Alissa, Bronstain, Ludmila, Minami, Shoko, Arnold, Holly, Ke, Na, Rubin, Eric J., Furie, Barbara C., Furie, Bruce, Beckwith, Jon, Dutton, Rachel, Boyd, Dana
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366281/
https://ncbi.nlm.nih.gov/pubmed/25686372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1752
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